OrangerV1, Main, Exploration, bibRecord, 000C02

Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models

Identifieur interne : 000C02 ( Main/Exploration ); précédent : 000C01; suivant : 000C03

Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models

Auteurs : Protus Arrey Tarkang [Cameroun, Kenya] ; Faith A. Okalebo [Kenya] ; Lawrence S. Ayong [Cameroun] ; Gabriel A. Agbor [Cameroun] ; Anastasia N. Guantai [Kenya]

Source :

Malaria Journal [ 1475-2875 ] ; 2014.

RBID : PMC:4251988

English descriptors

KwdEn :
- Animals, Antimalarials (administration & dosage), Biological Products (administration & dosage), Blood (parasitology), Body Weight, Chemoprevention (methods), Disease Models, Animal, Herbal Medicine, Malaria (drug therapy), Malaria (prevention & control), Mice, Inbred BALB C, Parasitemia (drug therapy), Parasitemia (prevention & control), Rats, Wistar, Survival Analysis, Temperature, Treatment Outcome.
MESH :
- chemical , administration & dosage : Antimalarials, Biological Products.
- drug therapy : Malaria, Parasitemia.
- methods : Chemoprevention.
- parasitology : Blood.
- prevention & control : Malaria, Parasitemia.
- Animals, Body Weight, Disease Models, Animal, Herbal Medicine, Mice, Inbred BALB C, Rats, Wistar, Survival Analysis, Temperature, Treatment Outcome.

Abstract

Background

The emerging resistance of Plasmodium species to currently available anti-malarials remains a public health concern, hence the need for new effective, safe and affordable drugs. Natural products remain a reliable source of drugs. Nefang is a polyherbal anti-malarial of the Cameroonian folklore medicine with demonstrated in vitro antiplasmodial and antioxidant activities. It is composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum (leaves). This study aimed at investigating the suppressive, prophylactic and curative activities of Nefang in Plasmodium infected rodent models.

Methods

Systemic acute oral toxicity of Nefang aqueous and ethanol extracts was assessed in mice up to a dose of 5,000 mgkg⁻¹ body weight. BALB/c mice and Wistar rats were inoculated with Plasmodium chabaudi chabaudi and Plasmodium berghei, respectively, and treated with Nefang, the Mangifera indica bark/Psidium guajava combination and a Psidium guajava leaf aqueous extracts (75, 150, 300 and 600 mgkg⁻¹ bwt). Their schizonticidal activity was then evaluated using the Peter’s 4-day suppressive test). The prophylactic and curative (Rane’s Test) activity of Nefang was also evaluated by determining the parasitaemia, survival time, body weight and temperature in pre-treated rodents.

Results

Acute oral toxicity of the extract did not cause any observed adverse effects. Percent suppressions of parasitaemia at 600 mgkg⁻¹ bwt were as follows (P. berghei/P. chabaudi): Nefang – 82.9/86.3, Mangifera indica bark/Psidium guajava leaf combination extract – 79.5/81.2 and Psidium guajava leaf – 58.9/67.4. Nefang exhibited a prophylactic activity of 79.5% and its chemotherapeutic effects ranged from 61.2 – 86.1% with maximum effect observed at the highest experimental dose.

Conclusion

These results indicate that Nefang has excellent in vivo anti-malarial activities against P. berghei and P. chabaudi, upholding earlier in vitro antiplasmodial activities against multi-drug resistant P. falciparum parasites as well as its traditional use. Hence, Nefang represents a promising source of new anti-malarial agents.

Electronic supplementary material

The online version of this article (doi:10.1186/1475-2875-13-456) contains supplementary material, which is available to authorized users.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251988

DOI: 10.1186/1475-2875-13-456
PubMed: 25421605
PubMed Central: 4251988

Affiliations:

Cameroun, Kenya

Le document en format XML

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 infection in rodent models</title>
<author><name sortKey="Arrey Tarkang, Protus" sort="Arrey Tarkang, Protus" uniqKey="Arrey Tarkang P" first="Protus" last="Arrey Tarkang">Protus Arrey Tarkang</name>
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<country xml:lang="fr">Cameroun</country>
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<affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Pharmacology and Pharmacognosy, University of Nairobi, P. O. Box 19676–00202, Nairobi, Kenya</nlm:aff>
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<author><name sortKey="Ayong, Lawrence S" sort="Ayong, Lawrence S" uniqKey="Ayong L" first="Lawrence S" last="Ayong">Lawrence S. Ayong</name>
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<author><name sortKey="Guantai, Anastasia N" sort="Guantai, Anastasia N" uniqKey="Guantai A" first="Anastasia N" last="Guantai">Anastasia N. Guantai</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The emerging resistance of <italic>Plasmodium</italic>
 species to currently available anti-malarials remains a public health concern, hence the need for new effective, safe and affordable drugs. Natural products remain a reliable source of drugs. <italic>Nefang</italic>
 is a polyherbal anti-malarial of the Cameroonian folklore medicine with demonstrated <italic>in vitro</italic>
 antiplasmodial and antioxidant activities. It is composed of <italic>Mangifera indica</italic>
 (bark and leaf), <italic>Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum</italic>
 (leaves). This study aimed at investigating the suppressive, prophylactic and curative activities of Nefang in <italic>Plasmodium</italic>
 infected rodent models.</p>
</sec>
<sec><title>Methods</title>
<p>Systemic acute oral toxicity of Nefang aqueous and ethanol extracts was assessed in mice up to a dose of 5,000 mgkg<sup>−1</sup>
 body weight. BALB/c mice and Wistar rats were inoculated with <italic>Plasmodium chabaudi chabaudi</italic>
 and <italic>Plasmodium berghei,</italic>
 respectively, and treated with Nefang, the <italic>Mangifera indica</italic>
 bark/<italic>Psidium guajava</italic>
 combination and a <italic>Psidium guajava</italic>
 leaf aqueous extracts (75, 150, 300 and 600 mgkg<sup>−1</sup>
 bwt). Their schizonticidal activity was then evaluated using the Peter’s 4-day suppressive test). The prophylactic and curative (Rane’s Test) activity of Nefang was also evaluated by determining the parasitaemia, survival time, body weight and temperature in pre-treated rodents.</p>
</sec>
<sec><title>Results</title>
<p>Acute oral toxicity of the extract did not cause any observed adverse effects. Percent suppressions of parasitaemia at 600 mgkg<sup>−1</sup>
 bwt were as follows (<italic>P. berghei</italic>
/<italic>P. chabaudi</italic>
): Nefang – 82.9/86.3, <italic>Mangifera indica</italic>
 bark/<italic>Psidium guajava</italic>
 leaf combination extract – 79.5/81.2 and <italic>Psidium guajava</italic>
 leaf – 58.9/67.4. Nefang exhibited a prophylactic activity of 79.5% and its chemotherapeutic effects ranged from 61.2 – 86.1% with maximum effect observed at the highest experimental dose.</p>
</sec>
<sec><title>Conclusion</title>
<p>These results indicate that Nefang has excellent <italic>in vivo</italic>
 anti-malarial activities against <italic>P. berghei</italic>
 and <italic>P. chabaudi</italic>
, upholding earlier <italic>in vitro</italic>
 antiplasmodial activities against multi-drug resistant <italic>P. falciparum</italic>
 parasites as well as its traditional use. Hence, Nefang represents a promising source of new anti-malarial agents.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/1475-2875-13-456) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Oliveira, Ab" uniqKey="Oliveira A">AB Oliveira</name>
</author>
<author><name sortKey="Dolabela, Mf" uniqKey="Dolabela M">MF Dolabela</name>
</author>
<author><name sortKey="Braga, Fc" uniqKey="Braga F">FC Braga</name>
</author>
<author><name sortKey="Jacome, Rl" uniqKey="Jacome R">RL Jacome</name>
</author>
<author><name sortKey="Varotti, Fp" uniqKey="Varotti F">FP Varotti</name>
</author>
<author><name sortKey="Povoa, Mm" uniqKey="Povoa M">MM Povoa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castellanos, Jrg" uniqKey="Castellanos J">JRG Castellanos</name>
</author>
<author><name sortKey="Prieto, Jm" uniqKey="Prieto J">JM Prieto</name>
</author>
<author><name sortKey="Heinrich, M" uniqKey="Heinrich M">M Heinrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kong, Dx" uniqKey="Kong D">DX Kong</name>
</author>
<author><name sortKey="Li, Xj" uniqKey="Li X">XJ Li</name>
</author>
<author><name sortKey="Zhang, Hy" uniqKey="Zhang H">HY Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wagner, H" uniqKey="Wagner H">H Wagner</name>
</author>
<author><name sortKey="Ulrich Merzenich, G" uniqKey="Ulrich Merzenich G">G Ulrich-Merzenich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ginsburg, H" uniqKey="Ginsburg H">H Ginsburg</name>
</author>
<author><name sortKey="Deharo, E" uniqKey="Deharo E">E Deharo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ganesan, A" uniqKey="Ganesan A">A Ganesan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, Xh" uniqKey="Ma X">XH Ma</name>
</author>
<author><name sortKey="Zheng, Cj" uniqKey="Zheng C">CJ Zheng</name>
</author>
<author><name sortKey="Han, Ly" uniqKey="Han L">LY Han</name>
</author>
<author><name sortKey="Xie, B" uniqKey="Xie B">B Xie</name>
</author>
<author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name>
</author>
<author><name sortKey="Cao, Zw" uniqKey="Cao Z">ZW Cao</name>
</author>
<author><name sortKey="Li, Yx" uniqKey="Li Y">YX Li</name>
</author>
<author><name sortKey="Chen, Yz" uniqKey="Chen Y">YZ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="White, Nj" uniqKey="White N">NJ White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tarkang, Pa" uniqKey="Tarkang P">PA Tarkang</name>
</author>
<author><name sortKey="Okalebo, Fa" uniqKey="Okalebo F">FA Okalebo</name>
</author>
<author><name sortKey="Agbor, Ga" uniqKey="Agbor G">GA Agbor</name>
</author>
<author><name sortKey="Tsabang, N" uniqKey="Tsabang N">N Tsabang</name>
</author>
<author><name sortKey="Guantai, An" uniqKey="Guantai A">AN Guantai</name>
</author>
<author><name sortKey="Rukunga, Gm" uniqKey="Rukunga G">GM Rukunga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tarkang, Pa" uniqKey="Tarkang P">PA Tarkang</name>
</author>
<author><name sortKey="Atchan, Apn" uniqKey="Atchan A">APN Atchan</name>
</author>
<author><name sortKey="Kuiate, J" uniqKey="Kuiate J">J Kuiate</name>
</author>
<author><name sortKey="Okalebo, Fa" uniqKey="Okalebo F">FA Okalebo</name>
</author>
<author><name sortKey="Guantai, An" uniqKey="Guantai A">AN Guantai</name>
</author>
<author><name sortKey="Agbor, Ga" uniqKey="Agbor G">GA Agbor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tarkang, Pa" uniqKey="Tarkang P">PA Tarkang</name>
</author>
<author><name sortKey="Franzoi, Kd" uniqKey="Franzoi K">KD Franzoi</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Lee, E" uniqKey="Lee E">E Lee</name>
</author>
<author><name sortKey="Vivarelli, D" uniqKey="Vivarelli D">D Vivarelli</name>
</author>
<author><name sortKey="Freitas Junior, L" uniqKey="Freitas Junior L">L Freitas-Junior</name>
</author>
<author><name sortKey="Liuzzi, M" uniqKey="Liuzzi M">M Liuzzi</name>
</author>
<author><name sortKey="Tsabang, N" uniqKey="Tsabang N">N Tsabang</name>
</author>
<author><name sortKey="Ayong, Ls" uniqKey="Ayong L">LS Ayong</name>
</author>
<author><name sortKey="Agbor, Ga" uniqKey="Agbor G">GA Agbor</name>
</author>
<author><name sortKey="Okalebo, Fa" uniqKey="Okalebo F">FA Okalebo</name>
</author>
<author><name sortKey="Guantai, An" uniqKey="Guantai A">AN Guantai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Willcox, M" uniqKey="Willcox M">M Willcox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Handa, Ss" uniqKey="Handa S">SS Handa</name>
</author>
<author><name sortKey="Khanuja, Sps" uniqKey="Khanuja S">SPS Khanuja</name>
</author>
<author><name sortKey="Longo, G" uniqKey="Longo G">G Longo</name>
</author>
<author><name sortKey="Rakesh, Dd" uniqKey="Rakesh D">DD Rakesh</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Basir, R" uniqKey="Basir R">R Basir</name>
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Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models

Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models

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